Glycoproteins of lens membranes.

نویسندگان

  • R Garadi
  • F J Giblin
  • V N Reddy
چکیده

From the Department of Ophthalmology, the Oscar Johnson Institute, and the Division of Biostatistics, Washington University School of Medicine, St. Louis, Mo. This work was supported in part by NEI grants EY 00256 and EY 02687 (Dr. Moses) and NIGMS grant GM 28719 (Dr. Wette) from the National Institutes of Health, Bethesda, Md. Submitted for publication Aug. 17, 1981. Reprint requests: Robert A. Moses, M.D., Ophthalmology Box 8096, 660 South Euclid Ave., St. Louis, Mo. 63110.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Membrane glycoproteins of Philly mouse lens.

The Philly mouse is a new model for genetic cataracts, in which there is an apparent defect in lens membrane permeability. This abnormality results in electrolyte imbalance and lens hydration, typical of an osmotic cataract. Since membrane glycoproteins are believed to be involved in transport processes, we have studied the changes in these polypeptides in the Philly mouse lens during cataract ...

متن کامل

Spatial orientation of glycoproteins in membranes of rat liver rough microsomes. I. Localization of lectin-binding sites in microsomal membranes

Carbohydrate-containing structures in rat liver rough microsomes (RM) were localized and characterized using iodinated lectins of defined specificity. Binding of [125I]Con A increased six- to sevenfold in the presence of low DOC (0.04--0.05%) which opens the vesicles and allows the penetration of the lectins. On the other hand, binding of [125I]WGA and [125I]RCA increased only slightly when the...

متن کامل

Ocular Structural Glycoproteins

From the ocular connective tissues, relatively pure structural glycoproteins (SGP) are extractable by means of 8 m urea after trichloroacetic acid treatment. The SGP from corneal stroma (CSGP) and from sclera (SSGP) show considerable immunochemical similarities and are not related to SGP from anterior lens capsule (LSGP). An antiserum directed against the total connective tissue fraction of cor...

متن کامل

Ocular Structural Glycoproteins

From the ocular connective tissues, relatively pure structural glycoproteins (SGP) are extractable by means of 8 m urea after trichloroacetic acid treatment. The SGP from corneal stroma (CSGP) and from sclera (SSGP) show considerable immunochemical similarities and are not related to SGP from anterior lens capsule (LSGP). An antiserum directed against the total connective tissue fraction of cor...

متن کامل

SPATIAL ORIENTATION OF GLYCOPROTEINS IN MEMBRANES OF RAT LIVER R O U G H MICROSOMES I. Localization of Lectin-Binding Sites in Microsomal Membranes

Carbohydrate-containing structures in rat liver rough microsomes (RM) were localized and characterized using iodinated lectins of defined specificity. Binding of [l~sI]Con A increased sixto sevenfold in the presence of low DOC (0.040.05 %) which opens the vesicles and allows the penetration of the lectins. On the other hand, binding of [125I]WGA and [125I]RCA increased only slightly when the mi...

متن کامل

Effects of Gnidilatimonoein, from Daphne mucronata, on the plasma membrane glycoproteins in two cancerous cell lines

Metastasis describes the ability of a tumor to invade normal tissue and generate secondary tumors at sites distant from the primary tumor. The mechanism responsible for the inhibition of tumor metastasis by different agents is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness. Certainly effective treatment of metasta...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Investigative ophthalmology & visual science

دوره 22 4  شماره 

صفحات  -

تاریخ انتشار 1982